Pharmacology 343, Biochemical Foundations of Therapeutics, Fall 2007
Text: Lehninger; Principles of Biochemistry, 4th edition by Nelson and Cox. Publisher: Freeman, 2005.
Time: 10:00-10:50, Monday, Wednesday and Friday, 1044 NPC.
Instructors: Dr. John C. Matthews (Office - 307 Faser); Dr. Ziaeddin Shariat-Madar (Office - 317 Faser)
e-mail; pljcm@olemiss.edu madar@olemiss.edu
TA: Ravi Goyal; rgoyal@olemiss.edu
The objective of this course is for the students to acquire a working level of knowledge and comprehension of biochemistry, and to learn how an understanding of the principles of biochemistry is important in understanding the role of pharmaceutical care in wellness and disease.
The final exam will be cumulative and will count 30% of the grade for the course. In addition, there will be two 1-hr exams during the semester with each counting 25% of the course grade. These exams will be given from 7:30 to 8:50 AM on the dates specified.
Each student will be assigned to a topic research and presentation group during the semester. Several class periods (Fridays) will be used for these presentations. Each group is required to prepare a 20 minute presentation on the assigned topic. This presentation will be given to the rest of the class on the date specified. The presentation MUST relate the assigned topic to the current lecture material. The first requirement of the presentation is that it be informative. Presentations that are both informative and entertaining will receive the highest grades (keep it clean). Each member of the group must participate in the preparation and presentation. Each group will provide the rest of the class with a handout covering the important points of the presentation. The handout can be one or two pages, but not more than two pages. Include your names and citations for the sources of information used to prepare your presentation on your handout. Copies of the handout can be obtained by taking the original to the pharmacology department secretary in room 303 Faser. Performance and participation in this portion will count 10% of the final grade. Normally there will be one grade given for the group but under some circumstances there may be different grades given for different individuals in the group. At the end of the presentations there will be a quiz covering information presented. These quizzes will be open notes and will count approximately 4% of the final grade for the course.
Most weeks there will be a case question assignment. You will be permitted to work with others in the class to do the research necessary to answer the weekly case questions. However, your answer must be your own. Identical answers from more than one student in the class will receive grades of zero. Weekly case question answers will be due at the end of the class period on the due date (Fridays). Answers must be typed, and unless otherwise indicated no more than 6 lines of type (not including citations). Each of the weekly case questions can be fully answered in one to three sentences. You are expected to confine your answers to this general guideline. You must also give citations for the sources of information that you used to obtain your answers. Excessively long answers will be penalized. The weekly case questions will count approximately 6% of the final grade.
Unannounced quizzes will be given occasionally during the last 15 minutes of the lecture period. These will count as extra credit. They may contain some material from the lecture given that day, as well as material from presentations and weekly case questions.
Attendance is strongly encouraged.
In accordance with the honor code of the University of Mississippi School of Pharmacy, students are reminded that cheating in any form will not be tolerated. Performance on all tests and assignments shall represent the individual work of the student unless otherwise instructed. Students are permitted to have and use tests from previous years from this course. Students taking this course for the first time are not permitted to have and use case questions and answers from previous years. Students repeating this course may not use case questions and answers from previous years.
Reasonable accommodation will be made for students with defined disabilities. It is the responsibility of the student to make such needs for accommodation known to the instructor at the onset of the course.
Grading scale: 90-100 A, 80-89.9 B, 70-79.9 C, 68-69.9 D, below 68 F
Reading approximate
assignment lecture schedule
chapter dates
1*,2 8/20,22,24 a. Water: polarity, hydrogen bonding, solubility,
hydrophobicity, hydrophilicity, pH, heat capacity
7*,10,11 8/27, 8/29,8/31 b. Lipids and membranes: fatty acids, phosphatides,
(pH tutorials) micelles, lipid bilayer, membranes, osmotic
(pH problems) pressure, Van Der Waals interactions, membrane
transport
3,4 9/5,10,12 c. Amino acids, polypeptides and proteins:
9/7,14 stud. pres. properties and biological functions of amino acids,
protein structure, biological functions of
polypeptides and proteins, denaturation
5,6 9/17,19,26,10/1 d. Enzymes: active site, substrate binding, catalysis,
9/21,28 stud.pres. Michaelis-Menten kinetics
Exam I 9/24
13-19,21.1 10/3,8,10,15,17 e. Intermediary metabolism: bioenergetics, Kreb's
22.1,22.2 10/24,29 tricarboxylic acid cycle, oxidative phosphorylation,
(appropriate 10/5,12, stud.pres. electron transport, fatty acid oxidation, fatty acid
sections) 10/19,26 stud.pres. synthesis, gluconeogenesis, glycogen synthesis,
glycogenolysis, triglyceride synthesis, fatty acid
mobilization, ketoacid metabolism
Help session 10/22
Exam II 10/24
14-16,19.3, 10/31,11/5,7,12,14, f. Regulation of metabolism: enzyme inhibition and
26,28 activation, proenzymes, (enzyme protein kinases,
(appropriate 11/2,9,16 stud.pres. calcium homeostasis, cyclic nucleotides, inositol
sections) 11/31 stud. pres. phosphate and diacylglyceride, hormones, receptor
mechanisms, biosignalling
__________________________________________________________________________
*reading material not covered in lecture, but covered on tests
| Educational Outcomes for PHCL 343 |
| General Education Abilities |
Outcome of this course |
| Critical Thinking, Analysis and Decision-Making "The student can find, understand, analyze, evaluate, and synthesize information and make informed, rational, and responsible decisions." |
major |
| Communication Skills "The student can communicate with various audiences by written, verbal, and electronic media for a variety of purposes." |
major |
| Mathematical Competence "The Student Is Proficient in the Expression of Quantitative Relationships and Can Perform the Needed Mathematical Operations to Infer Their Consequences." |
major |
| Professional Education Abilities | Outcome of this course |
| Evaluate and interpret patient data | minor |
| Apply knowledge of medical terminology and abbreviations | minor |
| Apply knowledge of specified drugs and drug classes | minor |
| Apply knowledge of specific physiologic systems | minor |
| Apply knowledge of specific disease pathology and comorbid conditions | minor |
| Employ communication styles and techniques appropriate to the audience | minor |
| Retrieve, analyze, and interpret the professional, lay, and scientific literature to provide drug information to patients, their families, other involved health care providers and the public to optimize patient care | minor |
| Serve as reliable and credible source of drug information | minor |
| Effectively educate patients utilizing all appropriate communication modalities (verbal, written, other) | minor |
| Present effective educational programs and presentations to public and health care profession audiences | minor |
| Take responsibility for gathering new knowledge, in the development of self-learning skills to foster lifelong learning | minor |
| Demonstrate an ability to evaluate and utilize information resources | minor |
| Exhibit self-assessment behaviors, in the development of self-learning skills to foster lifelong learning | minor |