Jason Paris

Research Associate Professor of Pharmacology

• Faculty
• Instructor

• Email:

  parisj@olemiss.edu

• Office Location:

  315 Faser Hall

• Phone:

  662-915-3096

• Office Hours:

  By appointment

Dr. Paris is a Research Associate Professor of Pharmacology whose lab investigates the potential protective effects of natural products on addiction and neurodegenerative diseases.

Research Interests

My lab is funded to investigate the potential beneficial effects of cannabis constituents to reduce the viremic and neurodegenerative effects of HIV. Additionally, we collaborate with chemists and engineers to improve the delivery of anti-HIV therapeutics to the brain so that HIV can be eradicated. We also conduct behavioral work on addiction to investigate the capacity for natural products to reduce stress and anxiety, thereby ameliorating important drivers of relapse.

Publications

Allopregnanolone and neuroHIV: Potential benefits of neuroendocrine modulation in the era of antiretroviral therapy.

Age-related neuroendocrine, cognitive, and behavioral co-morbidities are promoted by HIV-1 Tat expression in male mice.

6,5-Fused Ring, C2-Salvinorin Ester, Dual Kappa and Mu Opioid Receptor Agonists as Analgesics Devoid of Anxiogenic Effects.

Pregnane steroidogenesis is altered by HIV-1 Tat and morphine: Physiological allopregnanolone is protective against neurotoxic and psychomotor effects.

Combined HIV-1 Tat and oxycodone activate the hypothalamic-pituitary-adrenal and -gonadal axes and promote psychomotor, affective, and cognitive dysfunction in female mice.