Research and Impact
We bring together scientists and researchers to advance the science of natural products.
Advancing natural products research through a comprehensive approach
Our work at NCNPR is built around a full life cycle of discovery, development and application, where each phase of research informs the next. Scientists from multiple disciplines collaborate to explore natural compounds from initial identification and isolation to understanding their effects in real-world applications.
This integrated approach enables us to translate promising discoveries into safe and effective natural product-based solutions through rigorous preclinical and clinical evaluation. By combining botanical expertise, chemical analysis, and biological sciences, we drive innovation and advance scientific findings.
Explore our areas of research and expertise to see how we’re transforming the field of natural product science.
Our research
Botany
Our botanical research is supported by experts in taxonomy, plant physiology and molecular biology, who identify and catalog species with potential therapeutic properties. By examining the physical and biological characteristics of plants, the botany team prepares samples for further analysis, enabling deeper exploration in chemistry, biology, and clinical research.
Biology
Our scientists delve into how natural compounds interact with biological systems. By studying their mechanisms of action and safety, the biology team provides insights into the therapeutic potential of compounds. This research is essential in determining how natural products can safely and effectively support health, bridging the gap between laboratory findings and real-world applications.
Chemistry
At NCNPR, our chemistry researchers identify and isolate bioactive compounds from plants and other natural sources. By examining the chemical structures and properties that contribute to therapeutic potential, the chemistry team enables the development of innovative natural products for applications such as mitigating chronic conditions, enhancing pest management, and developing antimicrobial agents.
Clinical Research
Our clinical research examines the safety and effectiveness of natural products through rigorous trials and studies, helping translate scientific discoveries into practical health solutions. By testing compounds in clinical settings, our researchers determine appropriate usage, dosages, and potential benefits for human health. This work provides essential evidence to guide healthcare providers and the public on safe and effective natural product use.
A 30-year legacy of impact
For 30 years, NCNPR has driven advancements in natural products research, setting new standards for the safety and efficacy of dietary supplements and helping to establish quality benchmarks that safeguard consumers. Our research partnerships, including long-term collaborations with the FDA, have led to critical guidelines for botanical safety, paving the way for evidence-based use of natural products in healthcare.
From developing novel antimicrobial agents and studying plant-based compounds with potential therapeutic effects to advancing the science of dietary supplements, our findings support not only regulatory standards but also help healthcare providers and consumers make informed decisions about natural products. As an FDA Center of Excellence, NCNPR continues to bridge science and public health, ensuring that products derived from nature are studied rigorously to meet the highest standards.
Learn about some of the work we’ve done in the past 30 years:
To address the global demand for immune-supportive products, NCNPR developed Immulina, an extract derived from Arthrospira platensis (commonly known as spirulina). Recognizing the potent immunostimulatory properties of specific polysaccharides within the plant, NCNPR researchers isolated and patented this extract. Their research demonstrated that Immulina can enhance resilience against viral infections, such as influenza, by activating resident macrophages and supporting the body’s adaptive immune response.
Evaluating immunological resilience to infection with Immulina®
In 2023, several food products containing tara protein flour, were linked to cases of liver injury and severe gastrointestinal distress. NCNPR researchers were pivotal in identifying baikiain, a compound found in tara flour, as a possible toxic agent responsible for these adverse reactions.
NCNPR’s findings prompted increased scrutiny of novel ingredients and highlighted the need for collaboration with regulatory agencies in evaluating food safety. Our work on has contributed to industry-wide standards for ingredient testing.
The surge in demand for immune-support supplements during the COVID-19 pandemic spotlighted elderberry products for their reputed antiviral properties. NCNPR researchers identified critical issues with the quality and labeling of these popular botanical supplements. Out of 30 evaluated products, 17 were found to have inaccurate labels, with some misbranded and others containing undeclared ingredients.
By employing advanced analytical techniques, NCNPR exposed discrepancies that underscored widespread industry challenges, including potential adulteration. This research informed consumers and regulatory bodies about the need for enhanced scrutiny and quality standards.
In 2013, the quality control practices of the botanical dietary supplement (BDS) industry were called into question after a controversial study using DNA barcoding was published. The results, later deemed fraudulent and retracted, led to significant public concern and a formal investigation by the New York Attorney General into the authenticity of BDS products. In response, NCNPR stepped in to clarify the appropriate use of DNA barcoding in verifying the composition of supplements.
Our researchers highlighted that while DNA barcoding is an effective tool for identifying plant species in raw materials, its accuracy diminishes in highly processed products where DNA may be degraded. NCNPR has developed a comprehensive DNA barcode library to authenticate botanical ingredients and stressed the need to combine barcoding with other analytical methods for reliable results. This approach set new industry standards for supplement verification and strengthened quality control protocols.
As harmful algal blooms increasingly threaten aquatic ecosystems and public health, the need for effective and environmentally friendly solutions has become urgent. Traditional chemical treatments for managing algae often pose risks to marine life and can lead to ecological imbalances. In response to this challenge, NCNPR developed NP20851, a natural algaecide derived from botanical sources.
Through extensive research and testing, NCNPR scientists have demonstrated the efficacy of NP20851 against various algal species while ensuring its safety for non-target organisms in aquatic environments.
In the late 1990s and early 2000s, concerns emerged about the potential interactions between herbal supplements and prescription medications, especially as the use of herbs like St. John’s Wort became more widespread.
NCNPR researchers conducted in-depth studies to investigate these interactions, focusing on the chemical and genetic properties. One notable finding was that certain plant compounds accelerated the metabolism of medications, which could lead to reduced drug efficacy, especially in cases where precise medication levels are critical, such as for organ transplant patients.
This research helped inform updated safety guidelines and raised awareness about the risks of herb-drug interactions, promoting a more informed approach to the use of herbal supplements alongside pharmaceuticals.
In 2015, OxyELITE Pro, a popular dietary supplement marketed for weight loss and performance enhancement, came under scrutiny following reports of severe liver injuries and cases of acute hepatitis. NCNPR researchers were at the forefront of investigating this concerning trend, especially as reformulated versions of the product continued to raise alarm. Their analysis identified synthetic compounds within OxyELITE Pro that were associated with these adverse health effects, confirming that certain formulations posed significant risks to consumers.
While turmeric and its active compound, curcumin, are widely recognized for their potential health benefits, one major limitation has been their low bioefficacy—curcumin's ability to be absorbed and utilized effectively in the body. NCNPR’s research addressed this critical challenge by focusing on improving the compound's delivery and therapeutic impact.
NCNPR researchers explored advanced delivery systems, including nanoparticles, liposomes, and curcumin conjugates, to enhance absorption and bioavailability. These systems were designed to overcome the challenges of curcumin’s rapid metabolism and elimination, ensuring sustained release and improved therapeutic outcomes. Their findings not only advanced the understanding of turmeric’s pharmacological properties but also paved the way for developing more effective dietary supplements and therapeutic formulations.