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Mo Maniruzzaman

Chair and Professor of Pharmaceutics and Drug Delivery and Research Professor in the Research Institute of Pharmaceutical Sciences

Mo Maniruzzaman

Research Interests

Work in Dr. Maniruzzaman’s lab focuses on pharmaceutical process engineering, continuous manufacturing and 3D printing of medicines including biologics and mRNA therapeutics. Additional projects focus on 3D bioprinting of scaffolds and smart medical implants as well as ultra-portable drug delivery devices.

  1. Additive Manufacturing via 3D printing and bioprinting of scaffolds and smart medical implants
  2. Next generation technologies for the delivery of biologics (proteins, mAbs), recombinant protein vaccines and mRNA therapeutics
  3. Microbial based drug delivery systems (bugs as drugs)
  4. Pharmaceutical manufacturing via Hot-melt Extrusion and process engineering
  5. Continuous co-crystallisations/ manufacturing/ PAT
  6. Taste masking of bitter APIs for paediatric drug delivery
  7. Engineering of novel polymeric filaments for medical implants and nano-composites

 

  • Innovative 3D printing technologies for pharmaceutical dosage forms and advanced drug delivery

  • Next generation platform technologies (i.e., SMART, MAGiC and MeET) for the delivery of biologics, vaccines and mRNA therapeutics

  • Microbial based drug delivery systems (bugs as drugs) – novel delivery systems and plasmid construction to express therapeutics

          

  • 3D bioprinting of novel biomaterials for tissue engineering

  • Sensors and smart biomaterials 

  • Continuous manufacturing and process engineering of pharmaceuticals/ medical devices

 

  • Dielectric heating for on-demand manufacturing of dosage forms 

Publications

Article

  1. *Darwesh YA, Zhang Y, Aghda NH, Alkadi F, Maniruzzaman M. Advanced 3D Electrospinning “Xspin” System: Fabrication of Bifiber Floating Oral Pharmaceutical Scaffolds for Controlled Drug Delivery. Molecular Pharmaceutics. 2024. https://doi.org/10.1021/acs.molpharmaceut.3c00982
  2. * Lu A, Duggal I, Daihom B, Zhang Y, Maniruzzaman M. Unraveling the Influence of Solvent Composition on Drop-on-Demand Binder Jet 3D Printed Tablets Containing Calcium Sulfate Hemihydrate. International Journal of Pharmaceutics, 2023. https://doi.org/10.1016/j.ijpharm.2023.123652
  3. *Lu A, Williams III RO, Maniruzzaman M. 3D printing of biologics—what has been accomplished to date? Drug Discovery Today, 2023, Accepted. https://doi.org/10.1016/j.drudis.2023.103823
  4. *Chakka J, Maniruzzaman M. A Proof-of-Concept Preparation of Lipid–Plasmid DNA Particles Using Novel Extrusion-Based 3D-Printing Technology, SMART. Molecular Pharmaceutics, 2023. https://doi.org/10.1021/acs.molpharmaceut.3c00783
  5. *Kulkarni V, Chakka J, Alkadi F, Maniruzzaman M. Veering to a Continuous Platform of Fused Deposition Modeling Based 3D Printing for Pharmaceutical Dosage Forms: Understanding the Effect of Layer Orientation on Formulation Performance. Pharmaceutics 2023, 15(5), 1324. https://doi.org/10.3390/pharmaceutics15051324
  6. *Wang J, Cui Z, Maniruzzaman M. Bioprinting: a focus on improving bioink printability and cell performance based on different process parameters. International Journal of Pharmaceutics 2023, 123020. https://doi.org/10.1016/j.ijpharm.2023.123020
  7. *Wang J, Ghosh D, Maniruzzaman M. Using bugs as drugs: administration of bacteria-related microbes to fight cancer. Advanced Drug Delivery Reviews. 2023, 114825. https://doi.org/10.1016/j.addr.2023.114825 (Part of “Emerging Voices in Drug Delivery” Collection)
  8. *Suryavanshi P, Wang J, Duggal I, Maniruzzaman M, Banerjee S. Four-Dimensional Printed Construct from Temperature-Responsive Self-Folding Feedstock for Pharmaceutical Applications with Machine Learning Modeling. Pharmaceutics 2023, 15(4), 1266. https://doi.org/10.3390/pharmaceutics15041266
  9. *Zhang Y, Thakkar R, Zhang J, Lu A, Duggal I, Pillai A, Wang J, Heshmati Aghda N, Maniruzzaman Investigating the Use of Magnetic Nanoparticles As Alternative Sintering Agents in Selective Laser Sintering (SLS) 3D Printing of Oral Tablets. ACS Biomedical Science & Engineering, 2023.https://doi.org/10.1021/acsbiomaterials.2c00299.
  10. *Pillai AR, Chakka J, Heshmati N, Zhang Y, Alkadi F, Maniruzzaman M. Multifunctional Three-Dimensional Printed Copper Loaded Calcium Phosphate Scaffolds for Bone Regeneration. Pharmaceuticals 2023, 16(3), 352. https://doi.org/10.3390/ph16030352
  11. *Ahmed J, Thomas L, Mulla M, Al-Attar H, Maniruzzaman M. Dry granulation of vitamin D3 and iron in corn starch matrix: Powder flow and structural properties. Food Research International, 2023, 112497. https://doi.org/10.1016/j.foodres.2023.112497
  12. *Suryavanshi P, Kawre S, Maniruzzaman M, Seth K, Banerjee S. Thermo-responsive self-folding feedstock with excellent shape memory programming. Chemical Papers, 2023. https://doi.org/10.1007/s11696-023-02693-8
  13. *Giri BR, Maniruzzaman M. Fabrication of Sustained-Release Dosages Using Powder-Based Three-Dimensional 3D Printing Technology. AAPS PharmSciTech 2022, 24 (1), 1-15. https://doi.org/10.1208/s12249-022-02461-z
  14. *Heshmati Aghda N, Zhang Y, Wang J, Lu A, Pillai AR, Maniruzzaman M. A Novel 3D Printing Particulate Manufacturing Technology for Encapsulation of Protein Therapeutics: Sprayed Multi Adsorbed-Droplet Reposing Technology (SMART). Bioengineering 2022, 9(11), 653; https://doi.org/10.3390/bioengineering9110653
  15. *Wang J, Heshmati Aghda N, Jiang J, Habib AM, Ouyang D, Maniruzzaman M. 3D bioprinted microparticles: Optimizing loading efficiency using advanced DoE technique and machine learning modeling. International Journal of Pharmaceutics 2022, 122302. https://doi.org/10.1016/j.ijpharm.2022.122302
  16. *Lu A, Zhang J, Jiang J, Zhang Y, Giri B, Kulkarni V, Heshmati Aghda N, Wang J, Maniruzzaman M. Novel 3D Printed Modular Tablets Containing Multiple Anti-Viral Drugs: A Case of High Precision Drop-on-Demand Drug Deposition. Pharmaceutical Research 2022, Accepted. DOI: 1007/s11095-022-03378-9. (Part of “Emerging Leaders in Pharmaceutical and Biomedical Sciences” Collection)
  17. *Ahmed J, Giri BR, Thomas L, Al-Attar H, Maniruzzaman M. Continuous manufacturing of vitamin D3 and iron enriched granules by means of a novel twin-screw dry granulation process. Powder Technology 2022, 412, 117975. https://doi.org/10.1016/j.powtec.2022.117975
  18. *Wang J, Maniruzzaman M. A global bibliometric and visualized analysis of bacteria-mediated cancer therapy. Drug Discovery Today 2022, https://doi.org/10.1016/j.drudis.2022.05.023
  19. *Santitewagun S, Thakkar R, Zeitler JA, Maniruzzaman M. Detecting Crystallinity Using Terahertz Spectroscopy in 3D Printed Amorphous Solid Dispersions. Molecular Pharmaceutics 2022, (Appeared on the Journal Cover for the July 4, 2022 Issue). https://doi.org/10.1021/acs.molpharmaceut.2c00163
  20. *Kulkarni VR, Kazi M, Shahba A A-W, Radhanpuri A, Maniruzzaman M. Three-Dimensional Printing of a Container Tablet: A New Paradigm for Multi-Drug-Containing Bioactive Self-Nanoemulsifying Drug-Delivery Systems (Bio-SNEDDSs). Pharmaceutics 2022, 14(5), 1082.
  21. *Ijaz U, Sohail M, Minhas MU, Khan S, Hussain Z, Kazi M, Shah SA, Mahmood SA, Maniruzzaman M. Biofunctional Hyaluronic Acid/κ-Carrageenan Injectable Hydrogels for Improved Drug Delivery and Wound Healing. Polymers 2022, 14(3) 376. https://doi.org/10.3390/polym14030376
  22. *Ding L, Brunaugh AD, Thakkar RC, Lee C, Zhao QJ, Kalafat J, Maniruzzaman M, Smyth HDC. Comparison of HPMC Inhalation-Grade Capsules and Their Effect on Aerosol Performance Using Budesonide and Rifampicin DPI Formulations. AAPS PharmSciTech 2022, 23(1) 1-13. https://doi.org/10.1208/s12249-021-02175-8.
  23. *Zhang J, Lu A, Thakkar R, Zhang Y, Maniruzzaman M. Development and Evaluation of Amorphous Oral Thin Films Using Solvent-Free Processes: Comparison between 3D Printing and Hot-Melt Extrusion Technologies. Pharmaceutics 2021, 13(10), 1613; https://doi.org/10.3390/pharmaceutics13101613.
  24. *Lam M, Khoshkhat P, Chamani M, Shahsavari S, Dorkoosh FA, Rajabi A, Maniruzzaman M, Nokhodchi A. In-depth multidisciplinary review of the usage, manufacturing, regulations & market of dietary supplements. Journal of Drug Delivery Science and Technology 2022, https://doi.org/10.1016/j.jddst.2021.102985
  25. *Thakkar R, Davis DA, Williams III RO, Maniruzzaman M. Selective Laser Sintering of a Photosensitive Drug: Impact of Processing and Formulation Parameters on Degradation, Solid State, and Quality of 3D-Printed Dosage Forms. Molecular Pharmaceutics, 2021.(Appeared on the Journal Cover for the October 4, 2021 Issue). https://doi.org/10.1021/acs.molpharmaceut.1c00557
  26. *Thakkar R, Jara MO, Swinnea S, Pillai AR, Maniruzzaman M. Impact of Laser Speed and Drug Particle Size on Selective Laser Sintering 3D Printing of Amorphous Solid Dispersions. Pharmaceutics 2021, 13(8), 1149; https://doi.org/10.3390/pharmaceutics13081149
  27. *Zhang J, Thakkar R, Kulkarni VR, Zhang Y, Lu A, Maniruzzaman M. Investigation of the Fused Deposition Modeling Additive Manufacturing I: Influence of the Process Temperature on the Quality and Crystallinity of the Dosages. AAPS PharmSciTech, 2021, In press. DOI: 10.1208/s12249-021-02094-8
  28. *Wang J, Zhang Y, Aghda NH, Pillai A, Thakkar R, Nokhodchi A, Maniruzzaman M. Emerging 3D printing technologies for drug delivery devices: Current status and future perspective. Advanced Drug Delivery Reviews, 2021, In press. https://doi.org/10.1016/j.addr.2021.04.019
  29. *Thakkar R, Zhang Y, Zhang J, Maniruzzaman M. Synergistic application of twin-screw granulation and selective laser sintering 3D printing for the development of pharmaceutical dosage forms with enhanced dissolution rates and physical properties. European Journal of Pharmaceutics and Biopharmaceutics, 2021, 163, 141-156.
  30. *Zhang Y, Davis DA, AboulFotouh K, Wang J, Williams D, Bhambhani A, Zakrewsky M, Maniruzzaman M, Cui Z, Williams III RO. Novel Formulations and Drug Delivery Systems to Administer Biological Solids. Advanced Drug Delivery Reviews, 2021, 172, 183-210.
  31. *Kulkarni V, Lu A, Maniruzzaman M. 3D Printing in Personalized Drug Delivery, American Pharmaceutical Review, 2021, 1-5.
  32. *Shi K, Salvage J, Maniruzzaman M, Nokhodchi A. Role of release modifiers to modulate drug release from fused deposition modelling (FDM) 3D printed tablets. International Journal of Pharmaceutics, 2021, 120315. doi: 10.1016/j.ijpharm.2021.120315
  33. *Arshad MS, Zahra AT, Zafar S, Zaman H, Akhtar A, Ayaz MM, Hussain A, Abbas N, Kucuk I, Chang M-W, Maniruzzaman M, Ahmad Z. Antibiofilm effects of macrolide loaded Microneedle patches: prospects in healing of infected wounds. Pharmaceutical Research. 2021. https://link.springer.com/article/10.1007/s11095-021-02995-0
  34. *Shi K, Woodbine L, Aviles-Espinosa R, Rendon-Morales E, Salvage J, Maniruzzaman M, Nokhodchi A. Magnetic field triggerable microporous PDMS sponge loaded with an anti-cancer drug, 5-fluorouracil. ACS Biomaterials Science and Engineering. 2020, In Press. https://pubs.acs.org/doi/10.1021/acsbiomaterials.0c01608
  35. *Al-Dulimi, M Z, Wallis, D Tan, M Maniruzzaman, A Nokhodchi. 3D printing technology as innovative solutions for biomedical applications. Drug Discovery Today. 2020, In press. https://doi.org/10.1016/j.drudis.2020.11
  36. *Wu Y, Woodbine L, Carr AM, Pillai A, Maniruzzaman M. 3D Printed Calcium Phosphate Cement (CPC) Scaffolds for Anti-Cancer Drug Delivery. Pharmaceutics. 2020, 12(11) 1077.  https://doi.org/10.3390/pharmaceutics12111077
  37. *Davis D, Thakkar R, Su Y, Williams III RO, Maniruzzaman M. Selective Laser Sintering 3-Dimensional Printing as a Single Step Process to Prepare Amorphous Solid Dispersion Dosage Forms for Improved Solubility and Dissolution Rate. Journal of Pharmaceutical Sciences, Journal of Pharmaceutical Sciences, 2021, 110(4) 1432-1443. (Appeared on the Journal’s Special Topic Cluster, April 2021)
  38. *Deck T, Munzenrieder N, Maniruzzaman M, Nokhodchi A. A Low-Cost Method to Prepare Biocompatible Filaments with Enhanced Physico-mechanical Properties for FDM 3D Printing. Current Drug Delivery, 2020, 17 (1), https://doi.org/10.2174/1567201817999201
  39. *Zhang J, Thakkar R, Zhang Y, Maniruzzaman M. Structure-Function Correlation and Personalized 3D Printed Tablets using a Quality by Design (QbD) Approach. International Journal of Pharmaceutics. 2020, In press. https://doi.org/10.1016/j.ijpharm.2020.119945
  40. *Zhang J, Thakkar R, Zhang Y, Maniruzzaman M. Microwave Induced Dielectric Heating for the On-demand Development of Indomethacin Amorphous Solid Dispersion Tablets. Journal of Drug Delivery Science and Technology. 2020, In press. https://doi.org/10.1016/j.jddst.2020.102109
  41. *Thakkar RC, Pillai AR, Zhang J, Zhang Y, Kulkarni V, Maniruzzaman M. Novel On-Demand 3-Dimensional (3-D) Printed Tablets Using Fill Density as an Effective Release-Controlling Tool. Polymers . 2020, 12(9), 1872.
  42. *AboulFotouh K, Zhang Y, Maniruzzaman M, Williams III RO, Cui R. Amorphous Solid Dispersion Dry Powder for Pulmonary Drug Delivery: Advantages and Challenges. International Journal of Pharmaceutics. 2020, 119711. In press
  43. *Wallis M, Al-Dulimi S, Tan DK, Maniruzzaman M, Nokhodchi A. 3D printing for enhanced drug delivery: current state-of-the-art and challenges. Drug Development and Industrial Pharmacy. 2020. In press.
  44. *Shi K, Aviles-Espinosa R, Rendon-Morales E, Woodbine L, Maniruzzaman M, Nokhodchi A. Novel 3D printed device with integrated macroscale magnetic field triggerable anti-cancer drug delivery system. Colloids and Surfaces B: Biointerfaces, 2020, 192, 111068.
  45. *Lam M, Commandeur D, Maniruzzaman M, Tan DK, Nokhodchi A.The crucial effect of water and co-solvent on Liqui-Pellet pharmaceutical performance. Advanced Powder Technology. 2020, 31(5), 1903-1914 https://doi.org/10.1016/j.apt.2020.02.025.
  46. *Tan DK, Maniruzzaman M, Nokhodchi A. Development and optimization of novel polymeric compositions for sustained release theophylline caplets (PrintCap) via FDM 3D printing. Polymers, 2020, 12(1), 27 https://doi.org/10.3390/polym12010027
  47. *Wu Y, Heikal L, Ferns G, Ghezzi P, Nokhodchi A, Maniruzzaman M, 3D Bioprinting of Novel Biocompatible Scaffolds for Endothelial Cell Repair. Polymers, 2019, 11(12), 1924; https://doi.org/10.3390/polym11121924.
  48. *Ahmed J, Mulla M, Joseph A, Ejaz M, Maniruzzaman M, Zinc oxide/clove essential oil incorporated type B gelatin nanocomposite formulations: A proof-of-concept study for 3D printing applications. Food Hydrocolloids, Volume 98, 2020, 105256.
  49. *Maniruzzaman M, Pharmaceutical Applications of Hot-Melt Extrusion: Continuous Manufacturing, Twin-Screw Granulations, and 3D Printing. Pharmaceutics, 2019, 11(5), 218.
  50. Shi K, Tan DK, Nokhodchi A, Maniruzzaman M, Drop-On-Powder 3D Printing of Tablets with an Anti-Cancer Drug, 5-fluorouracil. Pharmaceutics, 2019, 11(4), 150.
  51. Ahmad J, Mulla M, Maniruzzaman M,Rheological and Dielectric Behavior of 3D-Printable Chitosan/Graphene Oxide Hydrogels. ACS Biomaterials Science and Engineering, 2019. DOI: 10.1021/acsbiomaterials.9b00201.
  52. K, Tousif Ayyub, Moravkar, Kailas, Maniruzzaman, Mohammed and Amin, Purnima (2019) Effect of melt extrudability and melt binding efficiency of polyvinyl caprolactam polyvinyl acetate polyethylene glycol graft copolymer (Soluplus®) on release pattern of hydrophilic and high dose drugs. Materials Science and Engineering: C, 99. pp. 563-574. ISSN 0928-4931
  53. Pawar, Jaywant, Suryawanshi, Dilipkumar, Moravkar, Kailas, Aware, Rahul, Shetty, Vasant, Maniruzzaman, Mohammedand Amin, Purnima (2018) Study the influence of formulation process parameters on solubility and dissolution enhancement of efavirenz solid solutions prepared by hot-melt extrusion: a QbD methodology. Drug Delivery and Translational Research, 8 (6). pp. 1644-1657. ISSN 2190-393X
  54. Tan, Deck Khong, Maniruzzaman, Mohammed and Nokhodchi, Ali (2018) Advanced pharmaceutical applications of Hot-Melt Extrusion coupled with Fused Deposition Modelling (FDM) 3D printing for personalised drug delivery. Pharmaceutics, 10 (4). 203 1-23. ISSN 1999-4923
  55. Maniruzzaman, Mohammed, Nokhodchi, Ali and Williams III, Robert O (2018) Process engineering and pharmaceutical manufacturing technologies. Drug Delivery and Translational Research. ISSN 2190-393X
  56. Sawant, Kiran P, Fule, Ritesh, Maniruzzaman, Mohammed and Amin, Purnima D (2018) Extended release delivery system of metoprolol succinate using hot-melt extrusion: effect of release modifier on methacrylic acid copolymer. Drug Delivery and Translational Research. ISSN 2190-393X
  57. Majumder, Mridul, Rajabnezhad, Saeid, Nokhodchi, Ali and Maniruzzaman, Mohammed (2018) Chemico-calorimetric analysis of amorphous granules manufactured via continuous granulation process. Drug Delivery and Translational Research. ISSN 2190-393X
  58. Trivedi, Vivek, Nandi, Uttom, Maniruzzaman, Mohammed and Coleman, Nichola J (2018) Intercalated theophylline-smectite hybrid for pH-mediated delivery. Drug Delivery and Translational Research. ISSN 2190-393X
  59. Pawar, Jaywant N, Fule, Ritesh A, Maniruzzaman, Mohammed and Amin, Purnima D (2017) Solid crystal suspension of Efavirenz using hot melt extrusion: exploring the role of crystalline polyols in improving solubility and dissolution rate.Materials Science and Engineering: C, 78. pp. 1023-1034. ISSN 0928-4931
  60. Maniruzzaman, Mohammed, Ross, Steven A, Dey, Tumpa, Nair, Arun, Snowden, Martin J and Douroumis, Dennis (2017) A quality by design (QbD) twin—screw extrusion wet granulation approach for processing water insoluble drugs. International Journal of Pharmaceutics, 526 (1-2). pp. 496-505. ISSN 0378-5173
  61. Saeed, Shojaee, Nokhodchi, Ali and Maniruzzaman, Mohammed (2017) Evaluations of the effect of sodium metabisulfite on the stability and dissolution rates of various model drugs from the extended release polyethylene oxide matrices. Journal of Pharmaceutical Innovation, 12 (3). pp. 260-270. ISSN 1939-8042
  62. Hossain, Akter, Nandi, Uttom, Fule, Ritesh, Nokhodchi, Ali and Maniruzzaman, Mohammed (2017) Advanced surface chemical analysis of continuously manufactured drug loaded composite pellets. Journal of Colloid and Interface Science, 492. pp. 157-166. ISSN 0021-9797
  63. Maniruzzaman, Mohammed and Nokhodchi, Ali (2017) Advanced implantable drug delivery systems via continuous manufacturing process. Critical Reviews in Therapeutic Drug Carrier Systems, 33 (6). pp. 569-589. ISSN 0743-4863
  64. Maniruzzaman, M, Islam, M T, Scoutaris, N, Nair, A and Douroumis, Dennis (2017) Increased dissolution rates of tranilast solid dispersions extruded with inorganic excipients. Drug Development and Industrial Pharmacy. ISSN 0363-9045
  65. Maniruzzaman, Mohammed and Nokhodchi, Ali (2017) Continuous manufacturing via hot-melt extrusion and scale up: regulatory matters. Drug Discovery Today, 22 (2). pp. 340-351. ISSN 1359-6446
  66. Shojaee, Saeed, Nokhodchi, Ali and Maniruzzaman, Mohammed (2017) Evaluation of the drug solubility and rush ageing on drug release performance of various model drugs from the modified release polyethylene oxide matrix tablets. Drug Delivery and Translational Research, 7 (1). pp. 111-124. ISSN 2190-3948
  67. Nokhodchi, Ali, Al-Hamidi, Hiba, Adebisi, Adeola O, Asare-Addo, Kofi and Maniruzzaman, Mohammed (2017) The use of various organic solvents to tailor the properties of Ibuprofen-glucosamine HCl solid dispersions. Chemical Engineering Research and Design, 117. pp. 509-519. ISSN 0263-8762
  68. Kelidari, H R, Saeedi, M, Akbari, J, Morteza-semnani, K, Valizadeh, H, Maniruzzaman, Mohammed, Farmoudeh, Ali and Nokhodchi, Ali (2016) Development and optimisation of spironolactone nanoparticles for enhanced dissolution rates and stability. AAPS PharmSciTech, 18 (5). pp. 1469-1474. ISSN 1530-9932
  69. Maniruzzaman, Mohammed, Farias, Smirna, Slipper, Ian J, Boateng, Joshua S, Chowdhry, Babur Z, Nair, Arun and Douroumis, Dennis (2016) Development and optimization of ketoconazole oral strips by means of continuous hot-melt extrusion processing. Journal of Pharmacy and Pharmacology. ISSN 0022-3573
  70. Maniruzzaman, Mohammed, Islam, Muhammad T, Halsey, Sheelagh, Amin, Devyani and Douroumis, Dennis (2016) Novel controlled release polymer-lipid formulations processed by hot melt extrusion. AAPS PharmSciTech, 17 (1). pp. 191-199. ISSN 1530-9932
  71. Maniruzzaman, Mohammed and Douroumis, Dennis (2015) Continuous manufacturing and process analytical tools.International Journal of Pharmaceutics, 496 (1). pp. 1-2. ISSN 0378-5173
  72. Maniruzzaman, Mohammed, Nair, Arun, Renault, Maxcene, Nandi, Uttom, Scoutaris, Nicholaos, Farnish, Richard, Bradley, Michael S A, Snowden, Martin J and Douroumis, Dennis (2015) Continuous twin-screw granulation for enhancing the dissolution of poorly water soluble drug. International Journal of Pharmaceutics, 496 (1). pp. 52-62. ISSN 0378-5173
  73. Fule, Ritesh, Dhamecha, Dinesh, Maniruzzaman, Mohammed, Khale, Anubha and Amin, Purnima (2015) Development of hot melt co-formulated antimalarial solid dispersion system in fixed dose form (ARLUMELT): evaluating amorphous state and in vivo performance. International Journal of Pharmaceutics, 496 (1). pp. 137-156. ISSN 0378-5173
  74. Maniruzzaman, M, Nair, A, Scoutaris, N, Bradley, Michael S A, Snowden, M J and Douroumis, D (2015) One-step continuous extrusion process for the manufacturing of solid dispersions. International Journal of Pharmaceutics, 496 (1). pp. 42-51. ISSN 0378-5173
  75. Islam, Muhammad T, Scoutaris, Nikolaos, Maniruzzaman, Mohammed, Moradiya, Hiren G, Halsey, Sheelagh A, Bradley, Michael S A, Chowdhry, Babur Z, Snowden, Martin J and Douroumis, Dennis (2015) Implementation of transmission NIR as a PAT tool for monitoring drug transformation during HME processing. European Journal of Pharmaceutics and Biopharmaceutics, 96. pp. 106-116. ISSN 0939-6411
  76. Maniruzzaman, Mohammed and Douroumis, Dennis (2015) An in-vitro-in-vivo taste assessment of bitter drug: comparative electronic tongues study. Journal of Pharmacy and Pharmacology, 67 (1). pp. 43-55. ISSN 0022-3573
  77. Maniruzzaman, Mohammed, Pang, Jiayun, Morgan, David J and Douroumis, Dennis (2015) Molecular modeling as a predictive tool for the development of solid dispersions. Molecular Pharmaceutics, 12 (4). pp. 1040-1049. ISSN 1543-8384
  78. Maniruzzaman, M, Snowden, Martin J, Bradely, Mike S and Douroumis, D (2015) Studies of intermolecular interactions in solid dispersions using advanced surface chemical analysis. RSC Advances, 5 (91). pp. 74212-74219. ISSN 2046-2069
  79. Kaialy, Waseem, Maniruzzaman, Mohammed, Shojaee, Saeed and Nokhodchi, Ali (2014) Antisolvent precipitation of novel xylitol-additive crystals to engineer tablets with improved pharmaceutical performance. International Journal of Pharmaceutics, 477 (1-2). pp. 282-293. ISSN 0378-5173
  80. Islam, Muhammad T, Maniruzzaman, Mohammed, Halsey, Sheelagh A, Chowdhry, Babur Z and Douroumis, Dennis (2014)Development of sustained-release formulations processed by hot-melt extrusion by using a quality-by-design approach.Drug Delivery and Translational Research, 4 (4). pp. 377-387. ISSN 2190-393X
  81. Maniruzzaman, Mohammed, Islam, Muhammad T, Moradiya, Hiren G, Halsey, Sheelagh A, Slipper, Ian J, Chowdhry, Baburz, Snowden, Martin J and Douroumis, Dennis (2014) Prediction of polymorphic transformations of paracetamol in solid dispersions. Journal of Pharmaceutical Sciences, 103 (6). pp. 1819-1828. ISSN 0022-3549
  82. Maniruzzaman, Mohammed, Bonnefille, Marion, Aranyos, Attila, Snowden, Martin J and Douroumis, Dennis (2014) An in-vivo and in-vitro taste masking evaluation of bitter melt-extruded drugs. Journal of Pharmacy and Pharmacology, 66 (2). pp. 323-337. ISSN 0022-3573
  83. Moradiya, Hiren G, Islam, Muhammad T, Halsey, Sheelagh, Maniruzzaman, Mohammed, Chowdhry, Babur Z, Snowden, Martin J and Douroumis, D (2014) Continuous cocrystallisation of carbamazepine and trans-cinnamic acid via melt extrusion processing. CrystEngComm, 16 (17). p. 3573. ISSN 1466-8033
  84. Maniruzzaman, Mohammed, Boateng, Joshua S, Chowdhry, Babur Z, Snowden, Martin J and Douroumis, Dennis (2014) A review on the taste masking of bitter APIs: hot-melt extrusion (HME) evaluation. Drug Development and Industrial Pharmacy, 40 (2). pp. 145-156. ISSN 0363-9045
  85. Palmer, Dasha, Levina, Marina, Douroumis, Dionysios, Maniruzzaman, Mohammed, Morgan, David J, Farrell, Thomas P, Rajabi-Siahboomi, Ali R and Nokhodchi, Ali (2013) Mechanism of synergistic interactions and its influence on drug release from extended release matrices manufactured using binary mixtures of polyethylene oxide and sodium carboxymethylcellulose. Colloids and Surfaces B: Biointerfaces, 104. pp. 174-180. ISSN 0927-7765
  86. Maniruzzaman, Mohammed, Morgan, David J, Mendham, Andrew P, Pang, Jiayun, Snowden, Martin J and Douroumis, Dennis (2013) Drug–polymer intermolecular interactions in hot-melt extruded solid dispersions. International Journal of Pharmaceutics, 443 (1-2). pp. 199-208. ISSN 0378-5173
  87. Maniruzzaman, M, Rana, M M, Boateng, J S, Mitchell, J C and Douroumis, D (2013) Dissolution enhancement of poorly water-soluble APIs processed by hot-melt extrusion using hydrophilic polymers. Drug Development and Industrial Pharmacy, 39 (2). pp. 218-227. ISSN 0363-9045
  88. Douroumis, Dennis, Onyesom, Ichioma, Maniruzzaman, Mohammed and Mitchell, John (2013) Mesoporous silica nanoparticles in nanotechnology. Critical Reviews in Biotechnology, 33 (3). pp. 229-245. ISSN 0738-8551
  89. Vithani, K, Maniruzzaman, M, Slipper, I J, Mostafa, S, Miolane, C, Cuppok, Y, Marchaud, D and Douroumis, D (2013)Sustained release solid lipid matrices processed by hot-melt extrusion (HME). Colloids and Surfaces B: Biointerfaces, 110. pp. 403-410. ISSN 0927-7765
  90. Maniruzzaman, Mohammed, Boateng, Joshua S, Bonnefille, Marion, Aranyos, Attila, Mitchell, John C and Douroumis, Dennis (2012) Taste masking of paracetamol by hot-melt extrusion: An in vitro and in vivo evaluation. European Journal of Pharmaceutics and Biopharmaceutics, 80 (2). pp. 433-442. ISSN 0939-6411
  91. Maniruzzaman, Mohammed, Boateng, Joshua S, Snowden, Martin J and Douroumis, Dennis (2012) A review of hot-melt extrusion: process technology to pharmaceutical products. ISRN Pharmaceutics, 2012 (436763). pp. 1-9. ISSN 2090-6153
  92. Gryczke, Andreas, Schminke, Silke, Maniruzzaman, Mohammed, Beck, Julien and Douroumis, Dennis (2011) Development and evaluation of orally disintegrating tablets (ODTs) containing Ibuprofen granules prepared by hot melt extrusion. Colloids and Surfaces B: Biointerfaces, 86 (2). pp. 275-284. ISSN 0927-7765
  93. Rai, Dinesh, Maniruzzaman, Mohammed and Boateng, Joshua S. (2010) Development and characterisation of sodium alginate and HPMC films for mucosal drug delivery. International Journal of Biotechnology, 11 (3/4). pp. 169-181. ISSN 0963-6048

News Magazine Articles

  1. *Wang J, Maniruzzaman M. PART II: AI and Machine Learning in Drug Delivery – Next Big Thing in Industry? AAPS News Magazine, 2022. https://www.aapsnewsmagazine.org/aapsnewsmagazine/articles/2022/nov22/cover-story-nov22
  2. *Wang J, Maniruzzaman M. PART I: AI and Machine Learning in Drug Delivery – Next Big Thing in Industry? AAPS News Magazine, 2022. https://www.aapsnewsmagazine.org/aapsnewsmagazine/articles/2022/oct22/cover-story-oct22b
  3. *Kulkarni V, Lu A, Maniruzzaman M. 3D Printing in Personalized Drug Delivery, American Pharmaceutical Review, 2021, 1-5

Edited Special Issue

  1. *Guest Editor: Maniruzzaman M, Banerjee S, Williams III RO, SI: Additive Manufacturing and Artificial Intelligence/Machine Learning in AAPS PharmSci Tech 2022-2023 (on-going)
  2. *Guest Editor: Maniruzzaman M, ‘SI: 3D and 4D Printing of (Bio)Materials‘ in Polymers July 2020.
  3. *Guest Editors: Morales JO, Maniruzzaman M, Palma S, ‘SI: The use of 2D/3D printing for medicines‘ in Drug Dev. and Ind. Pharm.
  4. Guest editor: Maniruzzaman M, ‘SI: Pharmaceutical Applications of Hot-melt Extrusion’ in Pharmaceutics, 2019
  5. Guest editors: Maniruzzaman M, Williams III RO, Nokhodchi A, ‘SI: Process Engineering and Continuous Manufacturing’ in Drug Delivery and Translational Research (official journal of the Controlled Release Society)- 2018
  6. Guest editors: Maniruzzaman M and Douroumis D, ‘SI: Continuous Manufacturing and Process Analytical Tools’ in International Journal of Pharmaceutics; Volume 496, Issue 1, Pages 1-156 (30 December 2015)

Edited Book

  1. Maniruzzaman, Mohammed, ed. (2019) 3D and 4D printing in biomedical applications: process engineering and additive manufacturing. Wiley, Weinheim, Germany. ISBN 9783527344437
  2. Maniruzzaman, Mohammed, ed. (2015) Practical guide to hot-melt extrusion: continuous manufacturing and scale-up.Smithers Rapra, Shrewsbury, UK. ISBN 9781910242117

Book

  1. Maniruzzaman, Mohammed (2013) Hot-melt extrusion: process to novel pharmaceutical applications. Lap Lambert, Dusseldorf, Germany. ISBN 978365946968-8

Book Section

  1. *Thakkar R, Pillai AR, Kulkarni VR, Maniruzzaman M. Applicability of machine learning in three-dimensionally (3D) printed dosage forms. In: Philip A., Et al., (Ed) A Handbook of Artificial Intelligence in Drug Delivery. 2023, Pages 259-299. https://doi.org/10.1016/B978-0-323-89925-3.00010-1
  2. *Daniel A Davis, Rishi Thakkar, Mohammed Maniruzzaman, Dave A Miller, Robert O Williams. Emerging Technologies to Increase the Bioavailability of Poorly Water-Soluble Drugs. In: Williams III RO, Davis DA, Miller DA (ed) Formulating Poorly Water Soluble Drugs, Springer, pp 599-650.
  3. *Maniruzzaman, Mohammed, Pawar, Jaywant (2020) Hot-melt extrusion: a versatile technology. In: Adejare, Adeboye (ed) Remington (23rd Edition) The Science and Practice of Pharmacy, Academic Press (Elsevier), pp 645-653, ISBN 978-0-12-820007-0. https://doi.org/10.1016/B978-0-12-820007-0.00033-7
  4. Tan, Deck Khong, Nokhodchi, Ali and Maniruzzaman, Mohammed (2019) 3D and 4D printing technologies: innovative process engineering and smart additive manufacturing. In: Maniruzzaman, Mohammed (ed.) 3D and 4D Printing in Biomedical Applications. Wiley, pp. 25-52. ISBN 9783527344437
  5. Rust, Brett, Tsaponina, Olga and Maniruzzaman, Mohammed (2019) Recent innovations in additive manufacturing across industries: 3D printed products and FDA’s perspectives. In: Maniruzzaman, Mohammed (ed.) 3D and 4D Printing in Biomedical Applications. Wiley, pp. 443-462.
  6. Maniruzzaman, Mohammed (2015) Continuous manufacturing via hot-melt extrusion and scale-up: regulatory aspects. In:Maniruzzaman, Mohammed (ed.) Practical Guide to Hot-Melt Extrusion: Continuous Manufacturing and Scale-up. Smithers RAPRA, Shawbury, United Kingdom, pp. 121-136. ISBN 9781910242650
  7. Maniruzzaman, Mohammed (2015) Introduction to hot-melt extrusion, continuous manufacturing: scale-up via hot-melt extrusion. In: Maniruzzaman, Mohammed (ed.) Practical guide to hot-melt extrusion: continuous manufacturing and scale-up. Smithers RAPRA, Shawbury, United Kingdom, pp. 1-15. ISBN 9781910242650
  8. Maniruzzaman, Mohammed (2015) Solid-state engineering of drugs using melt extrusion in continuous process. In:Maniruzzaman, Mohammed (ed.) Practical guide to hot-melt extrusion: continuous manufacturing and scale-up. Smithers RAPRA, Shawbury, United Kingdom, pp. 63-71. ISBN 9781910242650
  9. Douroumis, Dennis, Onyesom, Ichioma, Maniruzzaman, Mohammed and Edwards, Mark (2011) Mesoporous silica nanoparticles as a drug delivery system. In: Vivero-Escoto, Juan (ed.) Silica Nanoparticles: Preparation, Properties and Uses. Nova Publishers, New York. ISBN 9781613244524

Education

B.S. Pharmaceutical Science, University of Greenwich (2009)

Ph.D. Pharmaceutical Science, University of Greenwich (2013)