Research

The University of Mississippi School of Pharmacy is globally recognized for its multidisciplinary research in discovering, developing, and translating innovative solutions to healthcare problems.

Research Areas

Scientist studying cannabis plants.

Dietary Supplements and Medical Cannabis

Through the research in this field you will be able to carve out your place in two in-demand industries to advance policy, research, and product design.

Student Pouring Water into a beaker.

Environmental Toxicology

Participate in research and educational activities seeking to identify and resolve environmental and human health issues.

Scientist filling test tubes

Medicinal Chemistry

In this interdisciplinary field of chemistry, biology, and pharmaceutical sciences, you will be involved in the development of new therapeutics for diseases.

student working on experiment

Pharmacognosy

In this research are you will research the chemistry and pharmacology of bioactive natural products and their application in disease treatments.

Scientists looking at data

Pharmacology

In this area research how chemical agents, including potential therapeutic candidates, act on biological systems.

Faculty's Research Expertise

Explore our research areas and discover what our outstanding faculty are up to.

Kristie Willet

I am working with fish doing awesome things.

Kristie Willet

I am working with fish doing awesome things.

Kristie Willet

I am working with fish doing awesome things.

Kristie Willet

I am working with fish doing awesome things.

Kristie Willet

I am working with fish doing awesome things.

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Want to get involved in Summer Undergraduate Research?

The program aims to provide educational science research opportunities at the University of Mississippi to undergraduate students seeking research experiences and considering a career in research or academia. The program provides students with opportunities to learn about cutting-edge STEM-related topics, develop presentation and communication skills, practice networking skills, and explore and develop their interest in cutting-edge STEM-related research. In addition, the program aims to educate students beyond lab specifics and nurture students for successful careers in STEM, graduate, and/or professional programs.

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Research Instrumentation

The specialized items of equipment shown below are housed within the Department of BioMolecular Sciences and are readily available for departmental graduate students and post-doctoral associates to utilize in the course of their research activities. The Department of BioMolecular Sciences at the University of Mississippi represents one of the most well-equipped, state-of-the-art biomolecular sciences departments in the USA. Although not exhaustive, below is a list of some of the technology we have at our disposal.

600 MHz NMR Spectrometer: Varian; 3mm inverse probe; variable temperature control (vtc) magic angle probe for the measurement of NMR data with micrograms of sample; water suppression and solid-state NMR

500 MHz NMR spectrometer: Agilient DD2; “OneNMR” probe for both high- and low-bands; equipped with Agilent 7620-AS autosampler with 96 sample capacity.

500 MHz NMR spectrometer: Agilient DD2; “OneNMR” probe for both high- and low-bands; equipped with Agilent 7620-AS autosampler with 96 sample capacity


500 MHz NMR spectrometer: Bruker Avance III HD; 5mm Prodigy CryoProbe400 MHz NMR spectrometer: Varian Mercury Plus; 3 mm broadband gradient probe; 50 sample changer


TWO – 400 MHz NMR spectrometer: Bruker Avance III HDTM; 5mm BBFO probe

400 MHz NMR spectrometer: Bruker Avance DRX; 3 mm dual probe; vtc.


400 MHz NMR spectrometer: Bruker Avance DRX; 3 mm inverse probe with a gradient; vtc.

Mississippi Center for Supercomputer Research (MCSR) currently has 3 supercomputers: Sequoia, Catalpa, and Maple.


1 – Microway Dual Intel Xeon WhisperStation 2.5 GHz 12-core workstation


1 – Microway WhisperStation 2.5 GHz Xeon 8-core workstations


3 – Microway WhisperStation Intel Xeon L5520 Nehalem 2.26 GHz 16-core workstations


3 – Microway WhisperStation Intel Xeon L5420 Harpertown 2.5 GHz 8-core workstations


3 – Linux workstations14- Windows computers


Molecular Modeling Software – Schrödinger, Gold, and MOE software suites


Campus licenses for CambridgeSoft ChemBioOffice and Gaussian.

(2) – Nikon Ti2-E motorized:

Inverted microscope with a Lambda DG-5 Ultra High-Speed Wavelength Switcher


HPLC-Mass Spectrometry

LC-MS Systems

(1) Waters Alliance HT LC/MS System consists of the Waters 2790 Separations Module, the Waters ZQ™ Mass Detector (Waters 996 Photodiode Array (PDA) Detector, and FractionLynx™ software.

 (2) Waters Alliance LC/MS Systems consists of Waters ZQ Mass Detector, Photodiode Array Detector, and Alliance HPLC system.

HPLC Systems

Five (5) Waters Alliance HPLC Systems: (UV, Diode Array, Evaporative Light Scattering detectors).

Four (4) Waters DeltaPrep 4000 series HPLC Systems: Equipped with preparative capability – from hundreds of milligrams to grams per run, a PrepLC Controller, a solvent delivery unit, an integral injector panel, a Rheodyne 7725I injector, and Waters 996 Photodiode Array or Waters 2487 Dual Wavelength Absorbance Detector.

High-Resolution Mass Spectrometry

Thermo Orbitrap Fusion Tribrid LC/MS with multiple fragmentation modes, including collisionally induced disassociating (CID), higher-energy collisional dissociation (HCD), and electron transfer disassociation (ETD)

Dionex Ultimate 3000 UHPLC

Integrated autosampler/fraction collector and UV detector

Polarimeter

Rudolph Autopol IV, a six-wavelength polarimeter equipped with stainless steel jacketed cells, for measuring optical rotations. Volumes accommodated range from 1.0 mL to 0.05 mL.

Fourier Transform Infrared Spectrophotometer

Bruker Vector33 FTIR, with NIR and MID FTIR capabilities, is equipped with a fiber optics accessory for remote sensing and a HYPERION IRScope with ATR capabilities for solid-phase analysis of chemically modified resins.

UV-VIS Spectrophotometer

Hewlett-Packard 8453 Diode-Array Biochemical Analysis Spectrophotometer equipped with 7-cell thermostatted multicell transport accessory and dedicated water circulator. Biochemical Analysis software suite allows for kinetic analysis and real-time monitoring.

Elemental Analysis

Perkin-Elmer CHN/SO Series II Analyzer
Elemental analyzer equipped with a 60-sample carousel for performing high-throughput elemental analyses. 

COMPex Pro 102 KrF
Excimer laser with a maximum output of 400 mJ/pulse at 248 nm

 

In Vitro Core

TopCount NXTTM Microplate Scintillation and Luminescence Counter

The In Vitro Core’s TopCount NXTTM analyzes six at a time and counts samples in 96- and 384-well microplates, as well as microcentrifuge tubes. The external plate stacker allows multiple assay plates for a high unattended counting capacity. The system automatically controls the counting chamber temperature to ensure a stable and reproducible counting environment. The TopCount NXTTM can be used for Cell proliferation, Receptor binding assay, Solid Phase RIA/LIA, Reporter gene assays, 51Cr release assays, HPLC fraction analysis, and Scintillation Proximity Assays (SPA).

UniFilter 96-well Harvester

The FilterMate Harvester is configured for harvesting UniFilter microplates with built-in GF/B® or GF/C® filters for analysis on the TopCount Microplate Scintillation and Luminescence Counters.

 

Tri-Carb 2900TR Liquid Scintillation Analyzer

The Tri-Carb 2900TR is a bench-top liquid scintillation analyzer used to measure small amounts of beta, gamma, and alpha radioactivity. The Tri-Carb features QuantaSmart instrument software. 

Eppendorf epMotion® 5075

The epMotion machine is an automated pipetting system. It can dispense any quantity from 1-1000 μL in anywhere from 1-12 channels.

Perkin Elmer Envision® 2013 Multilabel Reader

This machine is a fast-reading detector HTS reader. It includes two detectors, which allow for simultaneous wavelength reading and reading below emission. It has stackers as well as internal temperature control for samples being loaded. It also has alpha screen capabilities and uses software to show plate readouts.

Thermo Scientific REVCO RB150 Incubator

This incubator is designed to retain CO2 levels internally for samples as well as keep them at a temperature. Systems are designed to also “trap” external water. It offers thermal protection and insulation as well as a spacious room for samples.

HERMLE LabNet Z323K Centrifuge

This high-performance centrifuge has high-speed rotors capable of producing up to 26,810 x g. Higher speed and g-force allow this centrifuge to be used in a biological lab setting. Parameters are set using easy turn knobs while their values are shown on large digital displays. Speed can be set and displayed in rpm or rcf. It has a radius-correction feature, and braking intensity can be set to ten different levels. There is also a refrigeration system internally, so heating or cooling can take place inside the centrifuge.

Spectrometer

Olis DSM 20 CD for measurements of circular dichroism (CD).

Other Research Centers and Cores

Explore more of the research areas partnered with BMS.