Chemical Research

By employing analytical techniques like chromatography and spectroscopy, our researchers can identify and characterize the chemical compounds found in nature. This knowledge is used to investigate potential applications, including the development of bioactive compounds for human health and the exploration of natural alternatives for agrochemicals, pesticides, and herbicides.

The analytical chemists at NCNPR use advanced instrumentation to standardize and authenticate botanicals, detect contaminants and adulterants, and verify the claimed ingredients in dietary supplements or commercial products. By analyzing the chemical constituents and biological activities of plants, they aid in understanding potential applications. They are able to identify toxic or problematic compounds in natural products, such as pyrrolizidine alkaloids in Crotalaria and Senecio spp. Researchers are also able to investigate the absorption and metabolism of natural product compounds in the body to assess supplement or pharmaceutical safety.

Our computational chemists employ advanced molecular modeling, simulations and machine learning techniques to predict the chemical and biological attributes, including potential toxicities of natural products and their derivatives before undertaking tedious experimental validations. These exercises are critical for enabling informed decision-making when experimental data is limited. Collaborative efforts with other teams guide the rational design and optimization of novel compounds. 

With a focus on isolation, structure identification, and synthesis, our organic and medical researchers characterize bioactive compounds. Through chromatography, spectroscopy and computational modeling, the team optimizes compound structures and explores structure-activity relationships.